Organization and function of a dioxin-responsive enhancer.

نویسندگان

  • J M Fisher
  • L Wu
  • M S Denison
  • J P Whitlock
چکیده

The dioxin-responsive enhancer upstream of the CYP1A1 gene contains four copies of the recognition motif for the liganded Ah receptor. The results of deletion analyses, linker-scanning analyses, and the analysis of individual enhancer subdomains reveal that each copy of the motif contributes to the response of the enhancer to 2,3,7,8-tetrachlorodibenzo-p-dioxin. In the context of the dioxin-responsive enhancer, a GC box, representing the DNA binding site for Sp1 (or a related transcription factor), has no detectable intrinsic activity but enhances gene expression when linked to a recognition motif for the liganded Ah receptor, thereby producing a synergistic effect on enhancer function.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 265 17  شماره 

صفحات  -

تاریخ انتشار 1990